Galectin-3 is a protein with important biological functions. Scientific information about the role of galectin-3 in health and disease has been mounting since its first discovery approximately 20-years ago. One of the most well characterized effects is the galectin-3 dependent fibrosis. As we are approaching the time that galectin-3 maybe used clinically to help physicians make more informed decisions, this site provides updated information about galectin-3.
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New U.S. Cardiology article examines the protein, galectin-3, and its implication in fibrosis, adverse cardiac remodeling, and progression |
 [Abstract] For many with heart failure, including the elderly and those with a preserved ejection fraction, both risk stratification and treatment are challenging. For these large populations and others, there is increasing recognition of the role of cardiac fibrosis in the pathophysiology of heart failure. Galectin-3 is a novel biomarker of fibrosis and cardiac remodeling that represents an intriguing link between inflammation and fibrosis. In this article, we review the biology of galectin-3, recent clinical research, and its application in the management of heart failure patients. - deFilippi CR and Felker GM. Galectin-3 in Heart Failure–Linking Fibrosis, Remodeling, and Progression. US Cardiology. 2010;7(1):in press.
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Pubmed research
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Galectin-3 results from PubMed
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Matrilysin-1 (MMP7) cleaves galectin-3 and inhibits wound healing in intestinal epithelial cells.
Department of Medicine, Division of Gastroenterology, Johns Hopkins University, Baltimore, Maryland.
1 Related Citations
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Comparative Analysis of FcϵRI Expression Patterns in Patients With Eosinophilic and Reflux Esophagitis.
*Division of Gastroenterology, Children's Hospital Boston, USA daggerPathology Department, Brigham and Women's Hospital, Boston, MA, USA.
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Mutational tuning of galectin-3 specificity and biological function.
Lund University, Sweden;
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Latest news
BG Medicine Announces Peer-Reviewed Publication of The BioImage StudyKEY RESEARCH
- Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF study – Lok DJA, et al. February 11, 2010
- Galectin-3: a novel mediator of heart failure development and progression – de Boer RA, et al. August 06, 2009
- Galectin-3, a novel marker of macrophage activity, predicts outcome in patients with stable chronic heart failure. – Lok DJA, et al. March 06, 2007
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