Galectin-3: a novel mediator of heart failure development and progression – de Boer RA, et al.
Galectins have important regulatory roles in inflammation, immunity and cancer. This review article focuses on recent data regarding the role of galectin-3 in the pathophysiology of heart failure (HF). Galectin-3 is up-regulated in hypertrophied hearts, stimulates macrophage migration, fibroblast proliferation, and the development of fibrosis. Cardiac fibrosis and remodeling adversely impact outcomes in HF, being linked to disease progression. Measurement of galectin-3 in patients with HF may help identify patients at highest risk for readmission or death, potentially enabling care tailored to individual patient needs.
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